After the sudden collapse of her family, Mim Malone is dragged from her home in northern Ohio to the ''wastelands'' of Mississippi, where she lives in a medicated milieu with her dad and new stepmom. Before the dust has a chance to settle, she learns her mother is sick back in Cleveland. So she ditches her new life and hops aboard a northbound Greyhound bus to her real home and her real mother, meeting a quirky cast of fellow travelers along the way. But when her thousand-mile journey takes a few turns she could never see coming, Mim must confront her own demons, redefining her notions of love, loyalty, and what it means to be sane.